Patients with type II diabetes mellitus are usually not dependent on insulin for prevention of ketosis or maintenance of life. However, they often benefit from insulin therapy to control symptoms or correct disordered metabolism, and a temporary course may be used to adjust glucose control. In this article, Dr Skyler discusses underlying concepts that direct insulin therapy in type II diabetes. He also summarizes the present state of combination therapy in which insulin is paired with another glucose-lowering agent.
Original Publication Date: February 1997
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